CONFERENCE PROGRAM
Schedule and location of the conference
Conference Date
October 27-29，2023
Conference Venue
Zhangjiang Science Hall（ Shanghai, China）
Conference Chairs
Chairs： Changsheng Liu、Qingming Luo、Robert chunhua Zhao
Co-chairs： Xiangmei Chen、Dongxin Lin、Fu-Sheng Wang、Guanghui Liu
Friday，October 27，2023
Opening Ceremony（Speaker Only)
Place： Parkyard hotel
18:00 -19:00 Welcome speech
19:00 -21:00 Dinner
Saturday morning，October 28，2023
Main forum
09:00 -09:20 Leader speech
Academician
President of Shanghai University
leaders of Zhangjiang Group,etc
09:20-09:30 Proposal
“Cognitive Aging，Disease Prevention，and Treatment，and Shared Health”
09:30-10:00 Targeting Hypoxia-Inducible Factors for the Treatment of Cancer and Blinding Eye Diseases
Gregg L. Semenza（USA）
Director, Vascular Program, Institute for Cell Engineering，Professor of Genetic Medicine，Johns Hopkins Medicine，Baltimore，United States
10:00-10:30 Summary of Expert Consensus
10:30-10:40 Cooperative contract signing
10:40-11:00 Group Photo & Coffee Break
Keynote Speeches
Conference Chairs: Stephen Dalton，Xiangmei Chen
11:00-11:30 Extending Healthspan in humans: Applying knowledge from Longevity research
Brian Kennedy（USA）
Distinguished Professor of Biochemistry & Physiology，Yong Loo Lin School of MedicineNational, University of Singapore
11:30-12:00 Mitochondrial Dysfunction as a Signature of Alzheimer's Disease: Insights from ATP11B
Robert chunhua Zhao
Director of the Department of Cell Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; Dean of the School of Life Sciences, Shanghai University
12:00-13:30 Lunch Break
Saturday afternoon，October 28，2023
Keynote speeches
Conference Chairs：Guanghui Liu， Eric Gilson
13:30-13:55 Decline of hippocampal TRF2 during aging triggers ATM-dependent memory impairment
Eric Gilson（France）
Telomere, senescence and cancer Eric GILSON, Director, Professor-Clinician, PU-PHCE
13:55-14:20 Genome Stability in aging, disease, and inheritance: new insights from C. elegans
Björn Schumacher（Germany）
Head of Research Area C – Principal Investigator，Chair for Genome Stability in Ageing and Disease，CECAD Research Center，University of Cologne
14:20-14:45 Using human brown adipocytes to develop new therapies for type II diabetes
Stephen Dalton（USA）
Global STEM scholar
14:45-15:10 Targeting senescence to rejuvenate the aged heart
Georgina Ellison-Hughes（UK）
Professor，Regenerative Muscle Physiology King's College London
15:10-15:30 Coffee Break
15:30-15:55 Programming and Reprogramming of Aging
Guanghui Liu
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
15:55-16:20 New Conopeptide Analgesic Development to Treat Chronic Pain Without Addiction
Sulan Luo
Distinguished Professor of Chang Jiang Scholars Program，Dean of Medical School, Guangxi University
Details of Expert Consensus
Conference Chairs： Ronghua Jin、Shengdi Chen
16:20-17:00 Details of Expert Consensus
Team Fu-Sheng Wang，Academician of Chinese Academy of Sciences，Director, Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital
Team Xiang Chen，Vice President of Central South University
Team Jiacan Su ，Director of Orthopedics Department, Xinhua Hospital, Shanghai Jiao Tong University
17:00-17:30 Mesocopic imaging for brain-wide neuronal networksand blood vessels during pathologic aging
Qingming Luo，Academician of Chinese Academy of Sciences，Fellow of the Chinese Academy of Medical Sciences，President of Hainan University
17:30-18:00 Details of Expert Consensus
Team Lin Chen，Professor of Surgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine
Team Jiangfeng Mao，Chief Physician of Beijing Union Medical College Hospital
Parallel Session 1 :Biomedical Imaging, Medical Devices and Disease
13:30-17:00
Session Chairs: Shengxian Tu、Xiaolei Zuo
13:30-13:50 Novel approaches to assess computational physiology and plaque vulnerability
Shengxian Tu
Distinguished Professor at the School of Biomedical Engineering, Shanghai Jiao Tong University,Director of Cardiovascular Innovative Instrument and Intelligent Computing lab
13:50-14:10 Bioprobes based on nucleic acid frameworks
Xiaolei Zuo
Vice Dean of the Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University
14:10-14:30 Mitochondria in stem cell fate and aging
Xingguo Liu
PI and Professor, Guangzhou Institutes of Biomedicine and Health
14:30-14:50 Illuminating Anti-aging
Yuan Guo
Professor，Northwest University, ChinaTargets identified from exercised heart: killing three birds with one stone
14:50-15:10 AI-based Radiomics technology in the precision medicine era for adult diffuse gliomas: what we have done in Huashan Hospital
Zhifeng Shi，M.D. PhD, associate chief neurosurgeon, associate professor of Department of Neurosurgery, Huashan Hospital, Fudan University.
15:10-15:20 Coffee Break
Session Chairs: Jian Xiao、Guoyuan Yang
15:20-15:40 Generic and Epigenetic Basis of Physical Fitness in Healthy Longevity
Christine Huang (Hongkong，China)
Managing Director of HK Longevity Medical Center
15:40-16:00 NRG1 Signaling Defines a Niche for Epidermal Progenitors in Wound Healing
Guohe Tan
Dean of School of Basic Medical Sciences, & Center for Translational Medicine,Guangxi Medical University
16:00-16:20 Rehabilitation of Age-Related Cognitive Impairment
Weijun Gong
Vice President of Beijing Rehabilitation Hospital Affiliated to Capital Medical University
16:20-16:40 Translational Research of Fibroblast growth factors in Wound Repair
Jian Xiao
Dean of Graduate School of Wenzhou Medical University
16:40-17:00 Neurotoxic Astrocytes Exacerbate Blood-Brain Barrier Disruption in Hemorrhagic Stroke via Matrix Metalloprotease 3
Guoyuan Yang
Vice Dean of Scientific Research, Med-X Research Institute, Shanghai Jiao Tong University
17:00-17:20 Study on targeted interventions for vascular remodeling of aortic dilation disease
Jian Zhou
Deputy Director of the Institute of Vascular Surgery of PLA
17:20-18:00 Poster session
Parallel Session 2 :Clinical Forum -Liver Cancer Diagnosis and Treatment Frontier
13:30-16:10
Session Chair: Feng Shen
13:30-13:50 Clinical application of integrated traditional Chinese and western medicine in the diagnosis and treatment of liver cancer
Changquan Ling
Professor，First Affiliated Hospital of Naval Medical University
13:50-14:10 Advances in the treatment of liver cancer
Jun Liang
Professor，Peking University International Hospital
14:10-14:30 Advances in perioperative treatment of hepatocellular carcinoma
Huichuan Sun
Professor，Zhongshan Hospital, Fudan University
14:30-14:50 The concept and practice of hepatectomy for liver cancer
Zhiyong Huang
Professor，Tongji Hospital, Huazhong University of Science and Technology
14:50-15:10 Coffee Break
Session Chair: Huichuan Sun
15:10-15:30 Immunomodulatory effect and clinical value of cryoablation therapy in comprehensive treatment of liver tumors
Zhiqiang Meng
Professor，Cancer Hospital Affiliated to Fudan University
15:30-15:50 Progress of systemic therapy for liver cancer from the perspective of disciplines
Xiufeng Liu
Professor，Eastern Theater General Hospital
15:50-16:10 Characteristics and prevention of postoperative recurrence of hepatocellular carcinoma
Tian Yang
Professor，Third Hospital, Naval Medical University
Parallel Session 3 :Clinical Forum - Breast Cancer Diagnosis and Treatment Frontier
13:30-16:20
Session Chair: Benzhong Wang
13:30-13:50 Breast cancer cohort in China
Zhigang Yu
Professor，Second Hospital of Shandong University
13:50-14:10 To explore the application of ADC drugs in the treatment of breast cancer from DB series study
Xi Wang
Professor，Sun Yat-sen University Cancer Hospital
14:10-14:30 Neoadjuvant strategies for breast cancer
Hongjian Yang
Professor，Zhejiang Cancer Hospital
14:30-14:50 The application and value of nanotechnology in the diagnosis and treatment of breast cancer
Xiangyi Kong
Professor，National Cancer Center, Cancer Hospital, Chinese Academy of Medical Sciences
14:50-15:10 Coffee Break
Session Chair: Lixue Xuan
15:10-15:30 Practical Experience of Breast Cancer Screening in Chin Rural Women
Qi Wang
Professor，Guangdong Maternal and Child Health Hospital
15:30-15:50 Research progress of BRCA-mutated breast cancer
Hengyu Li
Professor，the First Affiliated Hospital of Naval Medical University
15:50-16:20 Roundtable forum: New Clinical techniques for Breast cancer
Closed door meeting for Industry-University-Research Cooperation
20:00-21:00
Sunday morning,October 29,2023
Parallel Session 1: Aging and Disease
09:00-11:50
Session Chairs: Abbe de Vallejo、Zhenyu Ju
09:00-09:20 Protective roles of histone deacetylase SIRT2 in age-related cardiovascular diseases
Houzao Chen
Deputy Director of the Institute of Basic Medicine, Chinese Academy of Medical Sciences
09:20-09:40 Linking healthy longevity with robust immune function in a long-lived mouse model
Abbe de Vallejo（USA）
Tenured Associate Professor of Pediatrics and Immunology University of Pittsburgh School of Medicine
09:40-10:00 A Glimpse on Stem Cell and Organ Aging: The Common & Distinct Mechanisms
Zhenyu Ju
Dean of the Institute of Aging and Regenerative Medicine at Jinan University
10:00-10:20 Connecting Healthy People, Healthy Plant and Healthy Growth
Tina Woods（UK）
Director All-Party Parliamentary Group for Longevity，Co-Founder and CEO of Business for Health
10:20-10:40 Systemic regulation of bone aging and research on biological agents
Hui Xie
Director of the Sports System Injury Repair Research Center at Xiangya Hospital, Central South University
10:40-10:50 Coffee Break
Session Chairs: Houzao Chen、Brun Ulfhake
10:50-11:10 The Natural History of Skeletal Muscle Wasting during Ageing and Strategies to Alleviate this Disease
Brun Ulfhake（Sweden）
Professor，Division of Clinical Physiology Department of Laboratory Medicine Karolinska University Hospital
11:10-11:30 The Original Driving Force of Human Aging and Emerging Lines of Antiaging Interventions
Yu Sun
Researcher, Shanghai Academy of Sciences, Chinese Academy of Sciences/School of Medicine, Shanghai Jiao Tong University
11:30-11:50 The Neural Basis of Healthy Aging
Shiqing Cai
Researcher，Shanghai Institute of Plant Physiology & Ecology, Chinese Academy of Science
Parallel Session 2: Biomedicine and Disease
09:00-12:00
Session Chairs: Jian Li、Alex Zhavoronkov
09:00-09:15 Anti-infective Drug Discovery and Biosynthesis from Microorganisms Derived from Special Environments
Jianhua Ju
Dean of School of Pharmaceutical Sciences, Shandong University
09:15-09:30 Multi-modal Transformers for Aging Research and Target Discovery
Alex Zhavoronkov（USA）
CEO of Insilico Medicine
09:30-09:45 Healthy Longevity Medicine: from gerosciences into the clinic, optimizing healthspan along the lifespan
Evelyne Yehudit Bischof（Israel）
Professor, Shanghai University of Medicine and Health Sciences,Visiting professor, Tel Aviv University School of Medicine
09:45-10:00 Small molecules targeting RNA epigenetic proteins for anticancer therapy
Caiguang Yang
Researcher，the Shanghai Institute of Pharmacy, Chinese Academy of Sciences
10:00-10:15 Functional oligonucleotide drugs for targeting disease-related RNAs
Xinjing Tang
Professor and PI, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University
10:15-10:25 Coffee Break
Session Chairs: Ke Ding, Vincenzo Sorrentino
10:25-10:40 Trigonelline Is A Novel NAD+ Precursor With Muscle Longevity Benefits Across Species
Vincenzo Sorrentino（Singapore）
Assistant Professor，National University of Singapore Yong Loo Lin School of Medicine
10:40-10:55 Medicinal Chemistry Campaign Combating Clinical Resistance of Kinase Inhibitor Drugs
Ke Ding
Principal Investigator in Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Dean of School of Pharmaceutical Sciences, Jinan University
10:55-11:10 Structure function and drug action mechanism of drug targets for major diseases
Haitao Zhang
Researcher, School of Pharmacy, Zhejiang University
11:10-11:25 Probiotic Lactobacillus reuteri extends the lifespan of Drosophila melanogaster through insulin/IGF-1 signaling
Kyung Jin-Min（South Korea）
PhD, Associate Professor，Department of Biological Sciences，Inha University
11:25-11:40 Identification of intervenable sites and design of new drugs for aging targets based on artificial intelligence
Jian Zhang
Director, School of Medicine, Shanghai Jiaotong University
Parallel Session 3: Industry-university-research Cooperation Forum
09:00-11:50
Session Chair: Hengjun Gao
09:00-09:20 Consideration of product development for chronic disease management
Lianshan Zhang
Professor，Tsinghua University；Professor，University of Texas；Director，Tsinghua University Research Center in Shenzhen
09:20-09:40 Addressing Hereditary Ocular Diseases using AAV Gene Therapy
Bin Li
Chairman of Newforth Pharmaceuticals
09:40-10:00 Gene Delivery Detection – Application and practices of Revvity Life science
Felix Xu
General Manager, Market Development, Revvity
10:00-10:20 The ethical challenge in clinical trials of stem cell drugs
Shuang Peng
General Manager of Weineng Life Technology Group Co., Ltd
10:20-10:30 Coffee break
Session Chair: Lianshan Zhang
10:30-10:50 A new model for Clinical translational engineering CBDTM: A 20-year exploration
Hengjun Gao
Biochip National Engineering Research Center
10:50-11:10 Invasive vs Non-invasive, the junction of Brain-Computer Interface Applications
Xuyun Hua
Chief Medical Officer, Shanghai Aoyi Information Technology Co., Ltd
11:10-11:30 Accelerated aging of the society: A major challenge that requires accelerated development of the health industry
Weihai Yin
Chief Medical Officer, Shanghai Aoyi Information Technology Co., Ltd；Founding Vice Dean, School of Biomedical Engineering, Shanghai Jiao Tong University, and Vice Dean, Med-X Research Institute
11:30-11:50 Roundtable Forum：Creating an efficient mechanism for industry university research collaboration: What are the biggest opportunities and challenges for industry university research collaboration?
Jiefei Cheng, Managing Director, Otsuka (Shanghai) Pharmaceutical Research and Development Co., LTD
Yuyang Li, General Manager, Grand Science and Technology Park
Hongyan Xu, Chairman of Gill Biochemical (Shanghai) Co., LTD., Executive Vice president of Jiangsu Overseas Chinese Businessmen Association
Xinhua Liao, Professor, School of Life Sciences, Shanghai University
Hong He, Co-founder and President of Shanghai Zhonghuijin Investment Group Co., LTD
Brain-X Lnaugural Meeting
11:00-12:00
Sunday afternoon,October 29,2023
Parallel Session 1: Aging and Disease
13:00-16:30
Session Chairs: Patrizia Anna d'Alessio、Guohe Tan
13:00-13:20 Novel Longevity Compounds in the Context of Cellular Senescence
Perinur Bozaykut Eker（Turkey）
Molecular Biology & Genetics Acibadem University，Istanbul
13:20-13:40 Studies on the mechanism of hair follicle regeneration and its related diseases
Ji Li
Deputy Director of Department of Dermatology, Xiangya Hospital, Central South University
13:40-14:00 Small molecules effects on organ-specific cell senescence
Patrizia Anna d'Alessio（France）
Universities Paris René Descartes and Paris Sud.
14:00-14:20 Construction of non-human primate animal models
Qiang Su
Researcher, Institute of Neuroscience, Chinese Academy of Science
14:20-14:40 Using the smart hospital platform of internet hospital to address the challenges of aging population.
Michael Chunming Wang
Professor，Director of the Development Department of Smart Hospital at Renji Hospital, School of Medicine, Shanghai Jiao Tong University
14:40-14:50 Coffee Break
Session Chairs: Sasanka Chakrabarti、Yulin Ge
14:50-15:10 In Vivo Imaging of Early Vascular Degeneration in Age-related Cognitive Decline
Yulin Ge（USA）
President of International Society for Neurovascular Diseases (ISNVD) Professor, Department of Radiology Grossman School of Medicine New York University
15:10-15:30 Repurposing cyclosporine A as a neuroprotective drug for Parkinson’s disease: pre-clinical studies
Sasanka Chakrabarti（India）
Central Research Cell M M Institute of Medical Sciences & Research Maharishi Markandeshwar Deemed University，India
15:30-15:50 The role of telomere protein TRF2 in aging
Jing Ye
Deputy Director, Geriatric Center, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
15:50-16:10 Engineering Longevity – Computationally-Guided Reprogramming of Single-Cell Aging
Nan Hao（USA）
Professor Molecular Biology University of California San Diego
16:10-16:30 D-granule, a novel stress induced biomolecular condensate, acts as a regulatory hub for actin cytoskeleton remodeling
Huanxing Su（Macau, China）
Professor, Chinese Medical Research Institute, University of Macau
Parallel Session 2: Biomedicine and Disease
13:00-16:50
Session Chairs：Zhen Gu 、Huichang Bi
13:00-13:20 Fenofibrate reverses cellular senescence and acts as an anti-aging agent in mice through PPARα-CPT1C signaling pathway
Huichang Bi
Professor and Dean at the School of Pharmaceutical Sciences, Southern Medical University
13:20-13:40 Molecular Connections of Aging and Cancer
William Cho（Hongkong，China）
Biomedical Scientist the Department of Clinical Oncology Queen Elizabeth Hospital Hong Kong，China
13:40-14:00 The applications of Adenviral vectors in ATMPs
Min Liang
Founder/General Manager of Shanghai Jinsi Biotechnology Co., Ltd
14:00-14:20 Medial Prefrontal Cortex Stimulation: From Antidepressant to Memory Enhancement
Lee Wei Lim（Hong Kong，China）
Assistant Professor ，University of Hong Kong
14:20-14:40 Engineering Cells for Drug Delivery
Zhen Gu
Dean of College of Pharmaceutical Sciences at Zhejiang University
14:40-14:50 Coffee Break
Session Chairs：Huanxing Su、Stacy Hussong
14:50-15:10 Mapping the molecular pathways that link aging to Alzheimer’s disease
Stacy Hussong（USA）
Assistant Professor, Research Department of Biochemistry & Molecular Biology University of Oklahoma Health Sciences Center
15:10-15:30 Single-Cell Sequencing Informs That Mesenchymal Stem Cell Alleviates Renal Injury Through Regulating Kidney Regional Immunity in Lupus Nephritis
Xueyuan Bai
Professor，the First Medical Center of the General Hospital of the PLA
15:30-15:50 Histamine H1 receptor: A new target for glioblastoma treatment
Yang-Jing Yang
Associate Professor of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University
15:50-16:10 Systematic evaluation of preclinical safety and efficacy of mesenchymal stem cells to treat Crohn’s disease based on human intestinal organoids and mouse models
Hongcui Cao
Vice Dean of State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
16:10-16:30 Strategies and Practices of Pharmacodynamic Substances Research in Complex Systems of Traditional Chinese Medicine
Hua Yang
Vice Director of the Institute of Pharmacy, Professor, China Pharmaceutical University
Parallel Session 3 : Innovative Traditional Chinese Medicine and Disease
13:00-16:30
Session Chair：Lei Zhang
13:00-13:20 Identification of anti-tumor molecular targets and targeted therapy
Lijun Jia
Researcher，Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Director of the Institute of Traditional Chinese Medicine Oncology at Shanghai Institute of Traditional Chinese Medicine
13:20-13:40 The role and bio-targets of terpenoids in the anti-inflammatory activity of traditional Chinese medicine
Yiming Li
Professor, School of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine
13:40-14:00 The Mechanism of Traditional Chinese Medicine Promoting the Proliferation and Differentiation of Neural Stem Cells
Yinchu Si
Professor, Beijing University of Chinese Medicine
14:00-14:20 The Application of Traditional Chinese Medicine in Skin Barrier Restoration
Bin Li
Dean of Shanghai Dermatology Hospital
14:20-14:30 Coffee Break
Session Chair：Lijun Jia
14:30-14:50 Traditional Chinese Medicine meets Anti-Aging：From Substance to Mechanism
Lei Zhang
Professor, School of Pharmacy, Second Military Medical University
14:50-15:10 Symbiont-derived drug-like molecules
Renxiang Tan
Director of the Medical Biotechnology Laboratory at Nanjing University
15:10-15:30 HPS technology to ensure safty and promote high-quality planting of ginseng
Caiping Guo
Shanghai Guohuan Agricultural Technology Development Co., Ltd
15:30-15:50 Research on the Inheritance and International Standardization of Pestle Needle Therapy for National Intangible Cultural Heritage
Xiaohong Fan
Vice Secretary and Professor of the Party Committee of the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine
16:00-17:00 Visit the Shanghai Museum of Traditional Chinese Medicine
Parallel Session 4 : Youth Innovation Forum in Aging and Disease
13:00-15:50
Session Chairs : Yaohui Tang、Liangshan Mu
13:00-13:20 Prediction and assessment of brain injury in high-risk premature infants
Yangyu Zhao
Director of Obstetrics and Gynecology, Peking University Third Hospital
13:20-13:40 Strategy research and mechanism of ovarian cell homeostasis/activation state balance to maintain fertility
Yang Yu
Professor，Peking University Third Hospital
13:40-14:00 Neuro-immune crosstalk in aging
Wei-Na Jin
Director of Beijing Tiantan Hospital, Capital Medical University
14:00-14:20 Repopulation and replacement: the philosophy of microglia
Bo Peng
Professor, School of Brain Science, Fudan University
14:20-14:30 Coffee Break
Session Chairs : Qin Hu, Dechao Feng
14:30-14:50 Reversal Translation Research in Psychopharmacology
Zhen-Ge Luo
Executive Dean and Professor, School of Life Sciences and Technology, Shanghai University of Science and Technology
14:50-15:10 Revealing intrinsic heterogeneity in axon regeneration
Ji Hu
Professor, School of Life Science and Technology, Shanghai University of Science and Technology
15:10-15:30 Development and Application of Single-Cell Spatial Multi-Omics in System Biology
Gang Cao
Professor, School of Life and Health, Shenzhen University of Technology
Closing Ceremony
16:30-17:30
16:30-17:30 Outstanding poster award and closing remark
Chair： Changsheng Liu, Qingming Luo, Robert chunhua Zhao
Co-chair： Xiangmei Chen, Dongxin Lin, Fu-Sheng Wang, Guanghui Liu
Friday, October 27, 2023
Conference Registration
09:00 AM-06:00 PM Poster Set-Up and Registration
Parkyard Hotel Shanghai (registration) and Zhangjiang Science Hall (poster setup)
Opening Ceremony and Dinner（Speaker Only)
06:00 PM-07:00 PM Welcome and introduction
07:00 PM-09:00 PM Cocktail
Location: Parkyard Hotel Shanghai
Saturday morning, October 28 , 2023
Main forum
09:00 AM-09:20 AM Leader speech
Academician
President of Shanghai University
Leaders of Zhangjiang Group, etc）
09:20 AM-09:30 AM Proposal
Title: “Advancing Aging and Disease Research for a Healthier Tomorrow”
09:30 AM-10:00 AM Gregg L. Semenza（USA）, Director
Nobel laureate keynote speech
10:00 AM-10:30 AM Summary of Expert Consensus
10:30 AM-10:40 AM Cooperative contract signing
10:40 AM-11:00 AM Group Photo & Coffee Break
Keynote Speeches (Conference Chairs: Stephen Dalton, Xiangmei Chen)
11:00 AM-11:30 AM Brian Kennedy（USA）
Title: "Extending Healthspan in humans: Applying knowledge from Longevity research"
11:30 AM-12:00 AM Guanghui Liu (China)
Title: “Programming and Reprogramming of Aging”
12:00 AM-01:30 PM Lunch Break
Saturday afternoon, October 28 , 2023
Keynote speeches(Conference Chairs：Guanghui Liu、 Eric Gilson)
01:30 PM-01:55 PM Eric Gilson（France）
Title: "Decline of hippocampal TRF2 during aging triggers ATM-dependent memory impairment”
01:55 PM-02:20 PM Björn Schumacher（Germany）
Title: “Genome Stability in aging, disease, and inheritance: new insights from C. elegans”
02:20 PM--02:45 PM Stephen Dalton（USA）
Title: “Using human brown adipocytes to develop new therapies for type II diabetes”
02:45 PM-03:10 PM Georgina Ellison-Hughes（UK）
Title: "Targeting senescence to rejuvenate the aged heart”
03:10 PM-03:30 PM Coffee Break
03:30 PM-03:55 PM Robert chunhua Zhao(China)
Title: "Mitochondrial Dysfunction as a Signature of Alzheimer's Disease: Insights from ATP11B”
03:55 PM-04:20 PM Qingming Luo（China）
Title: "Mesocopic imaging for brain-wide neuronal networksand blood vessels during pathologic aging”
04:20 PM-05:45 PM
Details of Expert Consensus（Conference Chairs： Ronghua Jin、Shengdi Chen）
Fu-Sheng Wang, Academician of Chinese Academy of Sciences
Xiang Chen, Vice President of Central South University
Su Jiacan, Director of Orthopedics Department, Xinhua Hospital, Shanghai Jiao Tong University
Lin Chen, Professor of Surgery, Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine
Mao Jiangfeng, Chief Physician of Beijing Union Medical College Hospital
Parallel Session 1: Biomedical Imaging, Medical Devices and Disease
Session Chairs: Junjie Xiao、Xiaolei Zuo
01:30 PM-01:50 PM Xiaolei Zuo
Title: “Bioprobes based on nucleic acid frameworks”
01:50 PM-02:10 PM Xingguo Liu
Title: “Mitochondria in stem cell fate and aging”
02:10 PM-02:30 PM Jian Xiao
Title: “Translational Research of Fibroblast growth factors in Wound Repair”
02:30 PM-02:50 PM Junjie Xiao
Title: “Targets identified from exercised heart: killing three birds with one stone”
02:50 PM-03:10 PM Zhifeng Shi
Title: "AI-based Radiomics technology in the precision medicine era for adult diffuse gliomas: what we have done in Huashan Hospital”
03:10 PM-03:20 PM Coffee Break
Session Chairs: Shengxian Tu, Guoyuan Yang
03:20 PM-03:40 PM Tzipi Strauss（Israel）
Title: “Does longevity fits all？”
03:40 PM-04:00 PM Guohe Tan (China)
Title: “NRG1 Signaling Defines a Niche for Epidermal Progenitors in Wound Healing”
04:00 PM-04:20 PM Weijun Gong (China)
Title: “Rehabilitation of Age-Related Cognitive Impairment”
04:20 PM-04:40 PM Shengxian Tu (China)
Title: “Novel approaches to assess computational physiology and plaque vulnerability”
04:40 PM-05:00 PM Guoyuan Yang (China)
Title: “Neurotoxic Astrocytes Exacerbate Blood-Brain Barrier Disruption in Hemorrhagic Stroke via Matrix Metalloprotease 3”
05:00 PM-05:20 PM Jian Zhou (China)
Title: “Study on targeted interventions for vascular remodeling of aortic dilation disease”
Paralle Session 2: Clinical Forum 1
Coming Soon
Paralle Session 3 :Clinical Forum 2
Coming Soon
Closed door meeting for Industry-University-Research Cooperation
Coming Soon
Sunday morning, October 29,2023
Parallel Session 1: Aging and Disease
Session Chairs: Abbe de Vallejo, Zhenyu Ju
09:00 AM-09:20 AM Houzao Chen(China)
Title: "Protective roles of histone deacetylase SIRT2 in age-related cardiovascular diseases”
09:20 AM-09:40 AM Abbe de Vallejo (USA)
Title: "Linking healthy longevity with robust immune function in a long-lived mouse model”
09:40 AM-10:00 AM Zhenyu Ju (China)
Title: "A Glimpse on Stem Cell and Organ Aging: The Common & Distinct Mechanisms”
10:00 AM-10:20 AM Tina Woods (UK)
Title: "Connecting Healthy People, Healthy Plant and Healthy Growth”
10:20 AM-10:40 AM Yuan Guo (China)
Title: "Racing and chemical intervention of senescence”
10:40 AM-10:50 AM Coffee Break
Session Chairs: Houzao Chen, Brun Ulfhake
10:50 AM-11:10 AM Brun Ulfhake (Sweden)
Title: "The Natural History of Skeletal Muscle Wasting during Ageing and Strategies to Alleviate this Disease”
11:10 AM-11:30 AM Yu Sun (China)
Title: "The Original Driving Force of Human Aging and Emerging Lines of Antiaging Interventions”
11:30 AM-11:50 AM Shiqing Cai (China)
Title: “The Neural Basis of Healthy Aging”
11:50 AM-12:10 PM Shai Efrati (Israel)
Title: "The Hyperoxic-Hypoxic Paradox: Unraveling its Potential in Regenerative Medicine”
Parallel Session 2: Biomedicine and Disease
Session Chairs: Jian Li, Alex Zhavoronkov
09:00 AM-09:15 AM Jianhua Ju (China)
Title: “Anti-infective Drug Discovery and Biosynthesis from Microorganisms Derived from Special Environments”
09:15 AM-09:30 AM Alex Zhavoronkov (USA)
Title: "Multi-modal Transformers for Aging Research and Target Discovery”
09:30 AM-09:45 AM Sulan Luo (China)
Title: "New Conopeptide Analgesic Development to Treat Chronic Pain Without Addiction”
09:45 AM-10:00 AM Evelyne Yehudit Bischof (Israel)
Title: "Healthy Longevity Medicine: from gerosciences into the clinic, optimizing healthspan along the lifespan”
10:00 AM-10:15 AM Caiguang Yang (China)
Title: "Small molecules targeting RNA epigenetic proteins for anticancer therapy”
10:15 AM-10:30 AM Xinjing Tang (China)
Title: "Functional oligonucleotide drugs for targeting disease-related RNAs”
10:30 AM-10:40 AM Coffee Break
Session Chairs: Ke Ding、Vincenzo Sorrentino
10:40 AM-10:55 AM Vincenzo Sorrentino (Singapore)
Title: "Trigonelline Is A Novel NAD+ Precursor With Muscle Longevity Benefits Across Species”
10:55 AM-11:10 AM Ke Ding (China)
Title: "Medicinal Chemistry Campaign Combating Clinical Resistance of Kinase Inhibitor Drugs”
11:10 AM-11:25 AM Haitao Zhang (China)
Title: "Structure function and drug action mechanism of drug targets for major diseases”
11:25 AM-11:40 AM Kyung Jin-Min (South Korea)
Title: "Probiotic Lactobacillus reuteri extends the lifespan of Drosophila melanogaster through insulin/IGF-1 signaling”
11:40 AM-11:55 AM Jian Zhang (China)
Title: TBA
Parallel Session 3: Industry-University-Research Cooperation Forum
Coming Soon
Parallel Session 4: Clinical Forum 3
Coming Soon
Sunday afternoon, October 29, 2023
Parallel Session 1: Aging and Disease
Session Chairs: Patrizia Anna d'Alessio、Ilia Stambler
01:00 PM-01:20 PM Perinur Bozaykut Eker (Turkey)
Title: “Novel Longevity Compounds in the Context of Cellular Senescence”
01:20 PM-01:40 PM Ji Li (China)
Title: "Studies on the mechanism of hair follicle regeneration and its related diseases”
01:40 PM-02:00 PM Patrizia Anna d'Alessio (France)
Title: "Small molecules effects on organ-specific cell senescence”
02:00 PM-03:20 PM Qiang Sun (China)
Title: "Construction of non-human primate animal models”
02:20 PM-02:40 PM Ilia Stambler (Israel)
Title: "Recognizing degenerative aging as a medical condition to enable longevity interventions: research methodology, education, and policy”
02:40 PM-02:50 PM Coffee Break
Session Chairs: Sasanka Chakrabarti, Yulin Ge
02:50 PM-03:10 PM Yulin Ge (USA)
Title: "In Vivo Imaging of Early Vascular Degeneration in Age-related Cognitive Decline”
03:10 PM-03:30 PM Sasanka Chakrabarti (India)
Title: "Repurposing cyclosporine A as a neuroprotective drug for Parkinson's disease: pre-clinical studies”
03:30 PM-03:50 PM Jing Ye (China)
Title: "The role of telomere protein TRF2 in aging”
03:50 PM-04:10 PM Nan Hao (USA)
Title: "Engineering Longevity – Computationally-Guided Reprogramming of Single-Cell Aging”
04:10 PM-04:30 PM Huanxing Su (Macau, China)
Title: "D-granule, a novel stress induced biomolecular condensate, acts as a regulatory hub for actin cytoskeleton remodeling”
Parallel Session 2: Biomedicine and Disease
Session Chairs：Zhen Gu 、Huichang Bi
01:00 PM-01:20 PM Huichang Bi (China)
Title: "Fenofibrate reverses cellular senescence and acts as an anti-aging agent in mice through PPARα-CPT1C signaling pathway”
01:20 PM-01:40 PM William Cho (Hongkong，China)
Title: "Molecular Connections of Aging and Cancer”
01:40 PM-02:00 PM Lei Zhang (China)
Title: "Traditional Chinese Medicine meets Anti-Aging：From Substance to Mechanism”
02:00 PM-02:20 PM Lee Wei Lim (Hong Kong，China)
Title: "Medial Prefrontal Cortex Stimulation: From Antidepressant to Memory Enhancement”
02:20 PM-02:40 PM Zhen Gu (China)
Title: “Engineering Cells for Drug Delivery”
02:40 PM-02:50 PM Coffee Break
Session Chairs：Shaohua Yang、Stacy Hussong
02:50 PM-03:10 PM Aftab Ahmad Chattha (Pakistan)
Title: TBA
03:10 PM-03:30 PM Shaohua Yang (USA)
Title: “Vascular contribution to AD/ADRD”
03:30 PM-03:50 PM Stacy Hussong (USA)
Title: “Mapping the molecular pathways that link aging to Alzheimer's disease”
03:50 PM-04:10 PM Xueyan Bai (China)
Title: "Single-Cell Sequencing Informs That Mesenchymal Stem Cell Alleviates Renal Injury Through Regulating Kidney Regional Immunity in Lupus Nephritis”
04:10 PM-04:30 PM Hongcui Cao (China)
Title: "Systematic evaluation of preclinical safety and efficacy of mesenchymal stem cells to treat Crohn's disease based on human intestinal organoids and mouse models”
04:30 PM-04:50 PM Yinchu Si (China)
Title: "The Mechanism of Traditional Chinese Medicine Promoting the Proliferation and Differentiation of Neural Stem Cells”
Parallel Session 3: Innovative Traditional Chinese Medicine and Disease
Coming Soon
Parallel Session 4: Youth Innovation Forum in Aging and Disease
Session Chairs: Yaohui Tang、Liangshan Mu
01:00 PM-01:20 PM Yangyu Zhao (China)
Title: "Unfavourable intrauterine environment contributes to abnormal gut microbiome and metabolome in twins”
01:20 PM-01:40 PM Yang Yu (China)
Title: “Strategy research and mechanism of ovarian cell homeostasis/activation state balance to maintain fertility”
01:40 PM-02:00 PM Yan-Jiang Wang (China)
Title: "Rejuvenation of peripheral immune cells by bone marrow transplantation attenuates Alzheimer's disease-like pathologies and behavioural deficits in an APP/PS1 mouse model”
02:00 PM-02:20 PM Wei-Na Jin (China)
Title: “Neuro-immune crosstalk in aging”
02:20 PM-02:40 PM Bo Peng (China)
Title: “Repopulation and replacement: the philosophy of microglia”
02:40 PM-02:50 PM Coffee Break
Session Chairs: Qin Hu, Dechao Feng
02:50 PM-03:10 PM Zhen-Ge Luo (China)
Title: "Revealing intrinsic heterogeneity in axon regeneration”
03:10 PM-03:30 PM Ji Hu (China)
Title: "Reversal Translation Research in Psychopharmacology”
03:30 PM-03:50 PM
Gang Cao (China)
Title: “Development and Application of Single-Cell Spatial Multi-Omics in System Biology”
Closing Ceremony
04:30 PM-05:30 PM Outstanding poster award and closing remark
Monday，October 30,2023
TOUR/networking: Wuzhen trip